I found during testing this on a 1Gb Microdrive that the PCMCIA card services were suspending the storage device. Resume delay was causing problems if you were in the process of accessing a squash file system stored on the device at the time (or in my case apache was serving my static Wikipedia pages) - i.e. the squashfs driver would fail and start giving back empty portions of the fs. It's particularly bad on older Microdrives but could effect other CF cards. SD cards do not seem to be effected.
So strictly speaking, I would probably make this advice for other file systems that you are likely to run from files (i.e. cramfs). If you have a CF card that you haven't had these problems with when using something like cramfs then by all means give it a go.
- Andy